Clomiphene Citrate Capsules

Compounded: 6.25, 12.5 mg, 25 mg Capsule
Commercial: 50 mg Tablet


Clomiphene is a medication that is primarily used to treat female infertility by stimulating ovulation. It is also sometimes used off-label to treat male infertility, as well as to treat certain hormonal imbalances in both men and women.

In women, clomiphene works by blocking the action of estrogen in the body, which signals the brain to increase the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones then stimulate the ovaries to produce and release eggs, increasing the chances of conception.

In men, clomiphene can help to increase testosterone levels and improve sperm count and motility, which can be helpful in treating male infertility.

Common Side Effects

  • Hot flashes
  • Mood changes
  • Breast tenderness
  • Nausea
  • Headache
  • Blurred vision
  • Abdominal discomfort
  • Bloating

Rare but potentially serious side effects of clomiphene include:

  • Ovarian hyperstimulation syndrome (OHSS), which can cause severe pain or bloating in the abdomen, nausea and vomiting, and shortness of breath.
  • Multiple births, such as twins or triplets, which can increase the risk of complications during pregnancy and delivery.
  • Ectopic pregnancy, which occurs when a fertilized egg implants outside of the uterus.


















  • 1.Potashnik G, Lerner-Gava L, Genkin L, et al. Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study. Fertil Steril 1999;71:853-859.
  • 2.Serophene (clomiphene citrate) package insert. Rockland, MA: EMD Serono; 2010 June.
  • 3.Zuckerman H, Carmel S. The inhibition of lactation by clomiphene. J Obstet Gynaecol Br Commonw 1973;80:822-3.
  • 4.Kroboth PD, Slalek FS, Pittenger AL et al. DHEA and DHEA-S: a review. J Clin Pharmacol 1999;39:327—48.
  • 5.Dadhich, P., Ramasamy, R., Scovell, J., Wilken, N., & Lipshultz, L. (2017). Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men. Indian journal of urology : IJU : journal of the Urological Society of India. Retrieved May 5, 2023, from